Early Complete Molecular Response to First-Line Nilotinib in Two Patients with Chronic Myeloid Leukemia Carrying the p230 Transcript
Joint Authors
Caocci, Giovanni
Greco, Marianna
La Nasa, Giorgio
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-2, 2 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-11
Country of Publication
Egypt
No. of Pages
2
Main Subjects
Abstract EN
Chronic myeloid leukemia (CML) with the rare fusion gene e19a2, encoding a p230 protein, has been described in patients with typical or rather aggressive clinical course.
Although tyrosine kinase inhibitors (TKIs) induce a substantial cytogenetic and molecular response in all phases of CML, a minority of p230 positive patients have been treated with TKIs.
We report two cases of CML patients carrying the p230 transcript, who achieved fast and deep complete molecular response (CMR) after frontline treatment with nilotinib.
Our results suggest the use of nilotinib as frontline agent for the treatment of this CML variant.
American Psychological Association (APA)
Greco, Marianna& Caocci, Giovanni& La Nasa, Giorgio. 2013. Early Complete Molecular Response to First-Line Nilotinib in Two Patients with Chronic Myeloid Leukemia Carrying the p230 Transcript. Case Reports in Hematology،Vol. 2013, no. 2013, pp.1-2.
https://search.emarefa.net/detail/BIM-505020
Modern Language Association (MLA)
Greco, Marianna…[et al.]. Early Complete Molecular Response to First-Line Nilotinib in Two Patients with Chronic Myeloid Leukemia Carrying the p230 Transcript. Case Reports in Hematology No. 2013 (2013), pp.1-2.
https://search.emarefa.net/detail/BIM-505020
American Medical Association (AMA)
Greco, Marianna& Caocci, Giovanni& La Nasa, Giorgio. Early Complete Molecular Response to First-Line Nilotinib in Two Patients with Chronic Myeloid Leukemia Carrying the p230 Transcript. Case Reports in Hematology. 2013. Vol. 2013, no. 2013, pp.1-2.
https://search.emarefa.net/detail/BIM-505020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505020