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Insight into HIV of IFN-Induced Myxovirus Resistance 2 (MX2) Expressed by Traditional Chinese Medicine
Joint Authors
Lee, Wen-Yuan
Chen, Kuen-Bao
Chen, Calvin Yu-Chian
Chan, Yueh-Chiu
Hung, Tzu-Chieh
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Recently, an important topic of the acquired immunodeficiency syndrome (AIDS) had been published in 2013.
In this report, the expression of the IFN-induced myxovirus resistance 2 (MX2) had been defined the function to kill the human immunodeficiency virus (HIV).
The screening from the Traditional Chinese Medicine (TCM) database by simulating molecular docking and molecular dynamics could select candidate compounds, which may express MX2 against HIV.
Saussureamine C, Crotalaburnine, and Precatorine are selected based on the highest docking score and other TCM compounds.
The data from molecular dynamics are helpful in the analysis and detection of protein-ligand interactions.
According to the docking poses, hydrophobic interactions, and hydrogen bond with structure variations, this research could assess the interaction between protein and ligand interaction.
In addition to the detection of TCM compound efficacy, we suggest that Saussureamine C is better than the others in protein-ligand interaction and the structural variation to express MX2.
American Psychological Association (APA)
Hung, Tzu-Chieh& Lee, Wen-Yuan& Chen, Kuen-Bao& Chan, Yueh-Chiu& Chen, Calvin Yu-Chian. 2014. Insight into HIV of IFN-Induced Myxovirus Resistance 2 (MX2) Expressed by Traditional Chinese Medicine. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-505034
Modern Language Association (MLA)
Hung, Tzu-Chieh…[et al.]. Insight into HIV of IFN-Induced Myxovirus Resistance 2 (MX2) Expressed by Traditional Chinese Medicine. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-505034
American Medical Association (AMA)
Hung, Tzu-Chieh& Lee, Wen-Yuan& Chen, Kuen-Bao& Chan, Yueh-Chiu& Chen, Calvin Yu-Chian. Insight into HIV of IFN-Induced Myxovirus Resistance 2 (MX2) Expressed by Traditional Chinese Medicine. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-505034
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505034