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PET Radiopharmaceuticals for Imaging Integrin Expression : Tracers in Clinical Studies and Recent Developments
Joint Authors
Maschauer, Simone
Prante, Olaf
Haubner, Roland
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-11
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Noninvasive determination of integrin expression has become an interesting approach in nuclear medicine.
Since the discovery of the first 18F-labeled cyclic RGD peptide as radiotracer for imaging integrin αvβ3 expression in vivo, there have been carried out enormous efforts to develop RGD peptides for PET imaging.
Moreover, in recent years, additional integrins, including α5β1 and αvβ6, came into the focus of pharmaceutical radiochemistry.
This review will discuss the tracers already evaluated in clinical trials and summarize the preliminary outcome.
It will also give an overview on recent developments to further optimize the first-generation compounds such as [18F]Galacto-RGD.
This includes recently developed 18F-labeling strategies and also new approaches in 68Ga-complex chemistry.
Furthermore, the approaches to develop radiopharmaceuticals targeting integrin α5β1 and αvβ6 will be summarized and discussed.
American Psychological Association (APA)
Haubner, Roland& Maschauer, Simone& Prante, Olaf. 2014. PET Radiopharmaceuticals for Imaging Integrin Expression : Tracers in Clinical Studies and Recent Developments. BioMed Research International،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-505038
Modern Language Association (MLA)
Haubner, Roland…[et al.]. PET Radiopharmaceuticals for Imaging Integrin Expression : Tracers in Clinical Studies and Recent Developments. BioMed Research International No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-505038
American Medical Association (AMA)
Haubner, Roland& Maschauer, Simone& Prante, Olaf. PET Radiopharmaceuticals for Imaging Integrin Expression : Tracers in Clinical Studies and Recent Developments. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-505038
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505038