Effects of Korean Red Ginseng and HAART on vif Gene in 10 Long-Term Slow Progressors over 20 Years : High Frequency of Deletions and G-to-A Hypermutation
Joint Authors
Chang, Mee Soo
Cho, Young Keol
Kim, Jung Eun
Kim, Ba Reum
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
To investigate if Korean red ginseng (KRG) affects vif gene, we determined vif gene over 20 years in 10 long-term slowly progressing patients (LTSP) who were treated with KRG alone and then KRG plus HAART.
We also compared these data with those of 21 control patients who did not receive KRG.
Control patient group harbored only one premature stop codon (PSC) (0.9%), whereas the 10 LTSP revealed 78 defective genes (18.1%) (P<0.001).
The frequency of small in-frame deletions was found to be significantly higher in patients who received KRG alone (10.5%) than 0% in the pre-KRG or control patients (P<0.01).
Regarding HAART, vif genes containing PSCs were more frequently detected in patients receiving KRG plus HAART than patients receiving KRG alone or control patients (P<0.01).
In conclusion, our current data suggest that the high frequency of deletions and PSC in the vif gene is associated with KRG intake and HAART, respectively.
American Psychological Association (APA)
Cho, Young Keol& Kim, Ba Reum& Chang, Mee Soo& Kim, Jung Eun. 2013. Effects of Korean Red Ginseng and HAART on vif Gene in 10 Long-Term Slow Progressors over 20 Years : High Frequency of Deletions and G-to-A Hypermutation. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-505042
Modern Language Association (MLA)
Cho, Young Keol…[et al.]. Effects of Korean Red Ginseng and HAART on vif Gene in 10 Long-Term Slow Progressors over 20 Years : High Frequency of Deletions and G-to-A Hypermutation. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-505042
American Medical Association (AMA)
Cho, Young Keol& Kim, Ba Reum& Chang, Mee Soo& Kim, Jung Eun. Effects of Korean Red Ginseng and HAART on vif Gene in 10 Long-Term Slow Progressors over 20 Years : High Frequency of Deletions and G-to-A Hypermutation. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-505042
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505042