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Prediction of B-Cell Epitopes in Listeriolysin O, a Cholesterol Dependent Cytolysin Secreted by Listeria monocytogenes
Joint Authors
Jones, Morris S.
Carter, J. Mark
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Listeria monocytogenes is a gram-positive, foodborne bacterium responsible for disease in humans and animals.
Listeriolysin O (LLO) is a required virulence factor for the pathogenic effects of L.
monocytogenes.
Bioinformatics revealed conserved putative epitopes of LLO that could be used to develop monoclonal antibodies against LLO.
Continuous and discontinuous epitopes were located by using four different B-cell prediction algorithms.
Three-dimensional molecular models were generated to more precisely characterize the predicted antigenicity of LLO.
Domain 4 was predicted to contain five of eleven continuous epitopes.
A large portion of domain 4 was also predicted to comprise discontinuous immunogenic epitopes.
Domain 4 of LLO may serve as an immunogen for eliciting monoclonal antibodies that can be used to study the pathogenesis of L.
monocytogenes as well as develop an inexpensive assay.
American Psychological Association (APA)
Jones, Morris S.& Carter, J. Mark. 2014. Prediction of B-Cell Epitopes in Listeriolysin O, a Cholesterol Dependent Cytolysin Secreted by Listeria monocytogenes. Advances in Bioinformatics،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-505044
Modern Language Association (MLA)
Jones, Morris S.& Carter, J. Mark. Prediction of B-Cell Epitopes in Listeriolysin O, a Cholesterol Dependent Cytolysin Secreted by Listeria monocytogenes. Advances in Bioinformatics No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-505044
American Medical Association (AMA)
Jones, Morris S.& Carter, J. Mark. Prediction of B-Cell Epitopes in Listeriolysin O, a Cholesterol Dependent Cytolysin Secreted by Listeria monocytogenes. Advances in Bioinformatics. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-505044
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505044