Alzheimer’s Disease and Risk of Hip Fracture : A Meta-Analysis Study
Joint Authors
Ji, Hong-Fang
Zhao, Yan
Shen, Liang
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Background.
Alzheimer's disease (AD) is the most common cause of dementia in the elderly population.
Growing evidence supports that AD patients are at high risk for hip fracture, but the issue remains questionable.
The purpose of the present study is to perform a meta-analysis to explore the association between AD and risk of hip fracture.
Considering that bone mineral density (BMD) acts as a strong predictor of bone fracture, we also studied the hip BMD in AD patients.
Methods.
We searched all publications in Medline, SciVerse Scopus, and Cochrane Library published up to January 2012 about the association between AD and hip fracture or hip BMD.
Results.
There are 9 studies included in the meta-analysis.
The results indicate that AD patients are at higher risk for hip fracture (OR and 95% CI fixed: ES = 2.58, 95% CI = [2.03, 3.14]; dichotomous data: summary OR = 1.80, 95% CI = [1.54, 2.11]) than healthy controls.
Further meta-analysis showed that AD patients have a lower hip BMD (summary SMD = −1.12, 95% CI = [−1.34, −0.90]) than healthy controls.
Conclusions.
It was found that in comparison with healthy controls AD patients are at higher risk for hip fracture and have lower hip BMD.
American Psychological Association (APA)
Zhao, Yan& Shen, Liang& Ji, Hong-Fang. 2012. Alzheimer’s Disease and Risk of Hip Fracture : A Meta-Analysis Study. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-505087
Modern Language Association (MLA)
Zhao, Yan…[et al.]. Alzheimer’s Disease and Risk of Hip Fracture : A Meta-Analysis Study. The Scientific World Journal No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-505087
American Medical Association (AMA)
Zhao, Yan& Shen, Liang& Ji, Hong-Fang. Alzheimer’s Disease and Risk of Hip Fracture : A Meta-Analysis Study. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-505087
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505087