The Role of NMDA Receptor Subtypes in Short-Term Plasticity in the Rat Entorhinal Cortex
Joint Authors
Chamberlain, Sophie E. L.
Yang, Jian
Jones, Roland S. G.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-10-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
We have previously shown that spontaneous release of glutamate in the entorhinal cortex (EC) is tonically facilitated via activation of presynaptic NMDA receptors (NMDAr) containing the NR2B subunit.
Here we show that the same receptors mediate short-term plasticity manifested by frequency-dependent facilitation of evoked glutamate release at these synapses.
Whole-cell patch-clamp recordings were made from layer V pyramidal neurones in rat EC slices.
Evoked excitatory postsynaptic currents showed strong facilitation at relatively low frequencies (3 Hz) of activation.
Facilitation was abolished by an NR2B-selective blocker (Ro 25-6981), but unaffected by NR2A-selective antagonists (Zn2+, NVP-AAM077).
In contrast, postsynaptic NMDAr-mediated responses could be reduced by subunit-selective concentrations of all three antagonists.
The data suggest that NMDAr involved in presynaptic plasticity in layer V are exclusively NR1/NR2B diheteromers, whilst postsynaptically they are probably a mixture of NR1/NR2A, NR1/NR2B diheteromers and NR1/NR2A/NR2B triheteromeric receptors.
American Psychological Association (APA)
Chamberlain, Sophie E. L.& Yang, Jian& Jones, Roland S. G.. 2008. The Role of NMDA Receptor Subtypes in Short-Term Plasticity in the Rat Entorhinal Cortex. Neural Plasticity،Vol. 2008, no. 2008, pp.1-13.
https://search.emarefa.net/detail/BIM-505112
Modern Language Association (MLA)
Chamberlain, Sophie E. L.…[et al.]. The Role of NMDA Receptor Subtypes in Short-Term Plasticity in the Rat Entorhinal Cortex. Neural Plasticity No. 2008 (2008), pp.1-13.
https://search.emarefa.net/detail/BIM-505112
American Medical Association (AMA)
Chamberlain, Sophie E. L.& Yang, Jian& Jones, Roland S. G.. The Role of NMDA Receptor Subtypes in Short-Term Plasticity in the Rat Entorhinal Cortex. Neural Plasticity. 2008. Vol. 2008, no. 2008, pp.1-13.
https://search.emarefa.net/detail/BIM-505112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505112