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Association between Faecalibacterium prausnitzii Reduction and Inflammatory Bowel Disease : A Meta-Analysis and Systematic Review of the Literature
Joint Authors
Cao, Yuan
Shen, Jun
Ran, Zhi Hua
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Laboratory data suggests a reduction of Faecalibacterium prausnitzii (F.
prausnitzii) is confirmed both in fecal samples in inflammatory bowel disease (IBD) patients.
Numerous observational studies have suspected dysbiosis, an imbalance between protective and harmful bacteria to be relevant to the etiology and pathogenesis of IBD.
Methods.
Medline, EMBASE, Pubmed, and others.
were searched by 2 independent reviewers.
Of 48 abstracts reviewed, 11 studies met our inclusion criteria (subject N=1180).
Meta-analysis was performed with Review Manager 5.2.
Results.
The bacterial count of F.
prausnitzii in IBD patients was significantly lower (6.7888±1.8875) log10 CFU/g feces than healthy controls (7.5791±1.5812) log10 CFU/g feces; P<0.0001.
The Standardization Mean Difference of F.
prausnitzii in IBD patients was −0.94 (95% confidence interval [CI]: −1.07–−0.80).
Subgroup analyses revealed a trend toward a greater effect for CD (SMD: −1.13, 95% CI: −1.32–−0.94) when compared to UC (SMD: −0.78, 95% CI: −0.97–−0.60).
Conclusions.
The abundance of F.
prausnitzii was decreased in IBD patients compared with healthy controls.
Furthermore, the reduction of F.
prausnitzii and misbalance of the intestinal microbiota are particularly higher in CD patients with ileal involvement.
American Psychological Association (APA)
Cao, Yuan& Shen, Jun& Ran, Zhi Hua. 2014. Association between Faecalibacterium prausnitzii Reduction and Inflammatory Bowel Disease : A Meta-Analysis and Systematic Review of the Literature. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-505142
Modern Language Association (MLA)
Cao, Yuan…[et al.]. Association between Faecalibacterium prausnitzii Reduction and Inflammatory Bowel Disease : A Meta-Analysis and Systematic Review of the Literature. Gastroenterology Research and Practice No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-505142
American Medical Association (AMA)
Cao, Yuan& Shen, Jun& Ran, Zhi Hua. Association between Faecalibacterium prausnitzii Reduction and Inflammatory Bowel Disease : A Meta-Analysis and Systematic Review of the Literature. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-505142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505142