Lessons from Tau-Deficient Mice
Joint Authors
Ke, Yazi D.
van der Hoven, Julia
Wu, Christopher W.
De Silva, Dineeka M.
Suchowerska, Alexandra K.
Ittner, Lars M.
Ittner, Arne
van Eersel, Janet
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Both Alzheimer's disease (AD) and frontotemporal dementia (FTD) are characterized by the deposition of hyperphosphorylated forms of the microtubule-associated protein tau in neurons and/or glia.
This unifying pathology led to the umbrella term “tauopathies” for these conditions, also emphasizing the central role of tau in AD and FTD.
Generation of transgenic mouse models expressing human tau in the brain has contributed to the understanding of the pathomechanistic role of tau in disease.
To reveal the physiological functions of tau in vivo, several knockout mouse strains with deletion of the tau-encoding MAPT gene have been established over the past decade, using different gene targeting constructs.
Surprisingly, when initially introduced tau knockout mice presented with no overt phenotype or malformations.
The number of publications using tau knockout mice has recently markedly increased, and both behavioural changes and motor deficits have been identified in aged mice of certain strains.
Moreover, tau knockout mice have been instrumental in identifying novel functions of tau, both in cultured neurons and in vivo.
Importantly, tau knockout mice have significantly contributed to the understanding of the pathophysiological interplay between Aβ and tau in AD.
Here, we review the literature that involves tau knockout mice to summarize what we have learned so far from depleting tau in vivo.
American Psychological Association (APA)
Ke, Yazi D.& Suchowerska, Alexandra K.& van der Hoven, Julia& De Silva, Dineeka M.& Wu, Christopher W.& van Eersel, Janet…[et al.]. 2012. Lessons from Tau-Deficient Mice. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-505190
Modern Language Association (MLA)
Ke, Yazi D.…[et al.]. Lessons from Tau-Deficient Mice. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-505190
American Medical Association (AMA)
Ke, Yazi D.& Suchowerska, Alexandra K.& van der Hoven, Julia& De Silva, Dineeka M.& Wu, Christopher W.& van Eersel, Janet…[et al.]. Lessons from Tau-Deficient Mice. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-505190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505190