Neurobiology of Major Depressive Disorder
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We survey studies which relate abnormal neurogenesis to major depressive disorder.
Clinically, descriptive gene and protein expression analysis and genetic and functional studies revised here show that individual alterations of a complex signaling network, which includes the hypothalamic-pituitary-adrenal axis; the production of neurotrophins and growth factors; the expression of miRNAs; the production of proinflammatory cytokines; and, even, the abnormal delivery of gastrointestinal signaling peptides, are able to induce major mood alterations.
Furthermore, all of these factors modulate neurogenesis in brain regions involved in MDD, and are functionally interconnected in such a fashion that initial alteration in one of them results in abnormalities in the others.
We highlight data of potential diagnostic significance and the relevance of this information to develop new therapeutic approaches.
Controversial issues, such as whether neurogenesis is the basis of the disease or whether it is a response induced by antidepressant treatments, are also discussed.
American Psychological Association (APA)
Villanueva, Rosa. 2013. Neurobiology of Major Depressive Disorder. Neural Plasticity،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-505192
Modern Language Association (MLA)
Villanueva, Rosa. Neurobiology of Major Depressive Disorder. Neural Plasticity No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-505192
American Medical Association (AMA)
Villanueva, Rosa. Neurobiology of Major Depressive Disorder. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-505192
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505192