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Both Optimal Matching and Procedure Duration Influence Survival of Patients after Unrelated Donor Hematopoietic Stem Cell Transplantation
Joint Authors
Lange, Andrzej
Sedzimirska, Mariola
Koscinska, Katarzyna
Polak, Malgorzata
Dera-Joachimiak, Dorota
Sylwia, Mizia
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Eighty-six patients suffering from hematological malignancies, immunodeficiencies, and aplastic anemias received alloHSCT from unrelated donors.
Donors were selected from the BMDW files and further matching was performed according to the confirmatory typing procedure with the use of PCR SSP and that based on sequencing.
The time from the clinical request of the donor search to the final decision of clinicians accepting the donor was from 0.3 to 17.8 months (median 1.6).
Matching was analyzed at the allele level, and 50, 27, and 9 donor-recipient pairs were 10/10 matched, mismatched in one or more alleles, respectively.
In an univariate analysis we found better survival if patients were transplanted: (i) from donors matched 10/10 (P=0.025), (ii) not from female donor to male recipient (P=0.037), (iii) in female donation from those with ≤1 pregnancy than multiparous (P=0.075).
Notably, it became apparent that duration of the confirmatory typing process affected the survival (HR = 1.138, P=0.013).
In multivariate analysis only the level of matching and the duration of the matching procedure significantly affected the survival.
In conclusion, the duration of the matching procedure in addition to the level of matching should be considered as an independent risk factor of survival.
American Psychological Association (APA)
Sylwia, Mizia& Dera-Joachimiak, Dorota& Polak, Malgorzata& Koscinska, Katarzyna& Sedzimirska, Mariola& Lange, Andrzej. 2012. Both Optimal Matching and Procedure Duration Influence Survival of Patients after Unrelated Donor Hematopoietic Stem Cell Transplantation. Bone Marrow Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-505221
Modern Language Association (MLA)
Sylwia, Mizia…[et al.]. Both Optimal Matching and Procedure Duration Influence Survival of Patients after Unrelated Donor Hematopoietic Stem Cell Transplantation. Bone Marrow Research No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-505221
American Medical Association (AMA)
Sylwia, Mizia& Dera-Joachimiak, Dorota& Polak, Malgorzata& Koscinska, Katarzyna& Sedzimirska, Mariola& Lange, Andrzej. Both Optimal Matching and Procedure Duration Influence Survival of Patients after Unrelated Donor Hematopoietic Stem Cell Transplantation. Bone Marrow Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-505221
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505221