Investigation of Tenascin Expression in Endometriosis
Joint Authors
Simsek, Mehmet
Sapmaz, Ekrem
Cobanoglu, Bengu
Ozkan, Zehra Sema
Ilhan, Necip
Cilgin, Hasan
Atilgan, Remzi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
To evaluate the serum and tissue levels and local expression pattern of tenascin, a high molecular weight extracellular matrix protein, in eutopic and ectopic endometrium from patients with and without endometriosis and to compare the proliferative and secretory phase differences.
Materials and Methods.
Thirty women with endometriosis and fifteen women without endometriosis undergoing surgery for benign indications were included in the study.
Serum and tissue levels and proliferative and secretory phase expression patterns of tenascin in the ectopic and eutopic endometrium were analyzed with immunohistochemistry and immunoassays.
The results were compared with Mann-Whitney U test.
P values <0.05 were considered as statistically significant.
Results.
Tenascin expression was detected in both of eutopic and ectopic endometrium of women with and without endometriosis.
In immunohistochemical staining, intense staining of tenascin was observed in glandular cells of eutopic and ectopic endometrial tissue samples of both groups during secretory phase (P<0.01).
Eutopic and ectopic tissue levels of tenascin were higher than serum tenascin levels only secretory phase (P=0.02).
There was no significant difference between groups for tissue and serum levels of tenascin during cycle phases.
Conclusion.
Tenascin expression showed cyclic change on eutopic and ectopic endometrium.
American Psychological Association (APA)
Ozkan, Zehra Sema& Cilgin, Hasan& Atilgan, Remzi& Simsek, Mehmet& Cobanoglu, Bengu& Ilhan, Necip…[et al.]. 2012. Investigation of Tenascin Expression in Endometriosis. ISRN Pathology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-505228
Modern Language Association (MLA)
Ozkan, Zehra Sema…[et al.]. Investigation of Tenascin Expression in Endometriosis. ISRN Pathology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-505228
American Medical Association (AMA)
Ozkan, Zehra Sema& Cilgin, Hasan& Atilgan, Remzi& Simsek, Mehmet& Cobanoglu, Bengu& Ilhan, Necip…[et al.]. Investigation of Tenascin Expression in Endometriosis. ISRN Pathology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-505228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505228