Preparation and In Vitro Evaluation of Tacrolimus-Loaded Ethosomes
Joint Authors
Li, Guiling
Fan, Chao
Fan, Yating
Li, Xinru
Li, Mei
Wang, Xiaoning
Liu, Yan
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The main objective of the present work was to prepare and assess dermal delivery of tacrolimus-loaded ethosomes versus classic liposomes.
Both delivery systems were characterized for particle size, polydispersity index, and entrapment efficiency (EE), by dynamic laser diffraction and ultrafiltration or dialysis methods, respectively.
The results indicated that presence of ethanol in the formulations affected the particle size.
In addition, ultrafiltration method was selected to determine EE due to relatively short period as compared with dialysis method.
Ethosomes exhibited a significant higher EE and amount of drug in dermis in contrast to classic liposomes suggesting that ethosomes with higher entrapment capacity prompted more amount of tacrolimus to permeate through stratum corneum and reach the target of atopic dermatitis (AD).
Physical stability was very well for tacrolimus-loaded ethosomes under storage condition (4°C).
Our results demonstrated that the ethosomal system might be a promising candidate for dermal delivery of tacrolimus for AD.
American Psychological Association (APA)
Li, Guiling& Fan, Chao& Li, Xinru& Fan, Yating& Wang, Xiaoning& Li, Mei…[et al.]. 2012. Preparation and In Vitro Evaluation of Tacrolimus-Loaded Ethosomes. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-505253
Modern Language Association (MLA)
Li, Guiling…[et al.]. Preparation and In Vitro Evaluation of Tacrolimus-Loaded Ethosomes. The Scientific World Journal No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-505253
American Medical Association (AMA)
Li, Guiling& Fan, Chao& Li, Xinru& Fan, Yating& Wang, Xiaoning& Li, Mei…[et al.]. Preparation and In Vitro Evaluation of Tacrolimus-Loaded Ethosomes. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-505253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505253