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The Effects of N-Butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxamide against Leishmania amazonensis Are Mediated by Mitochondrial Dysfunction
Joint Authors
Sarragiotto, Maria Helena
Desoti, Vânia Cristina
Volpato, Hélito
Silva, Sueli de Oliveira
Ueda-Nakamura, Tânia
Nakamura, Celso Vataru
Panice, Manuela Ribeiro
Cogo, Juliana
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Leishmaniasis is a disease that affects millions of people worldwide.
The drugs that are available for the treatment of this infection exhibit high toxicity and various side effects.
Several studies have focused on the development of new chemotherapeutic agents that are less toxic and more effective against trypanosomatids.
We investigated the effects of N-butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxamide (C4) and its possible targets against L.
amazonensis.
The results showed morphological and ultrastructural alterations, depolarization of the mitochondrial membrane, the loss of cell membrane integrity, and an increase in the formation of mitochondrial superoxide anions in L.
amazonensis treated with C4.
Our results indicate that C4 is a selective antileishmanial agent, and its effects appear to be mediated by mitochondrial dysfunction.
American Psychological Association (APA)
Volpato, Hélito& Desoti, Vânia Cristina& Cogo, Juliana& Panice, Manuela Ribeiro& Sarragiotto, Maria Helena& Silva, Sueli de Oliveira…[et al.]. 2013. The Effects of N-Butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxamide against Leishmania amazonensis Are Mediated by Mitochondrial Dysfunction. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-505286
Modern Language Association (MLA)
Volpato, Hélito…[et al.]. The Effects of N-Butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxamide against Leishmania amazonensis Are Mediated by Mitochondrial Dysfunction. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-505286
American Medical Association (AMA)
Volpato, Hélito& Desoti, Vânia Cristina& Cogo, Juliana& Panice, Manuela Ribeiro& Sarragiotto, Maria Helena& Silva, Sueli de Oliveira…[et al.]. The Effects of N-Butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxamide against Leishmania amazonensis Are Mediated by Mitochondrial Dysfunction. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-505286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505286