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Estimating Cell Count and Distribution in Labeled Histological Samples Using Incremental Cell Search
Joint Authors
Hallgrímsson, Benedikt
Schmidt, Eric J.
Jamniczky, Heather A.
Sensen, Christoph W.
Soh, Jung
Xiao, Mei
Boughner, Julia C.
Meruvia-Pastor, Oscar E.
Source
International Journal of Biomedical Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-24
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Cell proliferation is critical to the outgrowth of biological structures including the face and limbs.
This cellular process has traditionally been studied via sequential histological sampling of these tissues.
The length and tedium of traditional sampling is a major impediment to analyzing the large datasets required to accurately model cellular processes.
Computerized cell localization and quantification is critical for high-throughput morphometric analysis of developing embryonic tissues.
We have developed the Incremental Cell Search (ICS), a novel software tool that expedites the analysis of relationships between morphological outgrowth and cell proliferation in embryonic tissues.
Based on an estimated average cell size and stain color, ICS rapidly indicates the approximate location and amount of cells in histological images of labeled embryonic tissue and provides estimates of cell counts in regions with saturated fluorescence and blurred cell boundaries.
This capacity opens the door to high-throughput 3D and 4D quantitative analyses of developmental patterns.
American Psychological Association (APA)
Meruvia-Pastor, Oscar E.& Soh, Jung& Schmidt, Eric J.& Boughner, Julia C.& Xiao, Mei& Jamniczky, Heather A.…[et al.]. 2011. Estimating Cell Count and Distribution in Labeled Histological Samples Using Incremental Cell Search. International Journal of Biomedical Imaging،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-505312
Modern Language Association (MLA)
Meruvia-Pastor, Oscar E.…[et al.]. Estimating Cell Count and Distribution in Labeled Histological Samples Using Incremental Cell Search. International Journal of Biomedical Imaging No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-505312
American Medical Association (AMA)
Meruvia-Pastor, Oscar E.& Soh, Jung& Schmidt, Eric J.& Boughner, Julia C.& Xiao, Mei& Jamniczky, Heather A.…[et al.]. Estimating Cell Count and Distribution in Labeled Histological Samples Using Incremental Cell Search. International Journal of Biomedical Imaging. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-505312
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505312