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Erectogenic and Aphrodisiac Effects of Butea frondosa Koenig ex Roxb. in Rats : Involvement of Enzyme Inhibition
Joint Authors
Dethe, Shekhar
Pandre, Manoj Kumar
Jamwal, Rohitash
Goswami, Sumanta Kumar
Inamdar, Mohammed Naseeruddin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Butea frondosa Koenig ex Roxb.
(BF) is traditionally used to manage male sexual disorders including erectile dysfunction (ED).
Methanol extract of BF (bark) inhibited Rho-kinase 2 (ROCK-II) enzyme activity in vitro with an IC50 of 20.29±1.83 μg/mL.
The relaxant effect of methanol extract of BF (MEBF) was studied on phenylephrine precontracted corpus cavernosum smooth muscle (CCSM) isolated from young rats.
The effect of MEBF treatment on sexual behaviour of both young (5 month) and aged (24 month) rats was also studied in addition to the influence on smooth muscle, collagen (collagen-I and -III) level in penis, and sperm characteristics of young and aged rats.
MEBF relaxed CCSM up to 21.77±2.57% and increased sexual behavior of young and aged rats.
This increase in sexual function could be attributed to ROCK-II inhibition and increase in ratio of smooth muscle to collagen level in rat penile tissue.
Increased sperm production and decreased defective sperms in young and aged rats corroborate the usefulness of Butea frondosa in male infertility in addition to ED.
American Psychological Association (APA)
Goswami, Sumanta Kumar& Inamdar, Mohammed Naseeruddin& Pandre, Manoj Kumar& Jamwal, Rohitash& Dethe, Shekhar. 2013. Erectogenic and Aphrodisiac Effects of Butea frondosa Koenig ex Roxb. in Rats : Involvement of Enzyme Inhibition. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-505332
Modern Language Association (MLA)
Goswami, Sumanta Kumar…[et al.]. Erectogenic and Aphrodisiac Effects of Butea frondosa Koenig ex Roxb. in Rats : Involvement of Enzyme Inhibition. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-505332
American Medical Association (AMA)
Goswami, Sumanta Kumar& Inamdar, Mohammed Naseeruddin& Pandre, Manoj Kumar& Jamwal, Rohitash& Dethe, Shekhar. Erectogenic and Aphrodisiac Effects of Butea frondosa Koenig ex Roxb. in Rats : Involvement of Enzyme Inhibition. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-505332
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505332