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Local Sympathetic Denervation of Femoral Artery in a Rabbit Model by Using 6-Hydroxydopamine In Situ
Joint Authors
Jin, Yufei
Fan, Jun-jun
Li, Fuhang
Pei, Guo-Xian
Bi, Long
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Both artery bundle and sympathetic nerve were involved with the metabolism of bone tissues.
Whether the enhancing effects of artery bundle result from its accompanying sympathetic nerve or blood supply is still unknown.
There is no ideal sympathetic nerve-inhibited method for the in situ denervation of artery bundle.
Therefore, we dipped the femoral artery in the 6-hydroxydopamine (6-OHDA) locally and observed its effect.
Compared with control group, the in situ treatment of 6-OHDA did not damage the normal structure of vascular bundle indicated by hematoxylin-eosin (HE) staining.
However, the functions of sympathetic nerve was completely inhibited for more than 2 weeks, and only a few function of sympathetic nerve resumed 4 weeks later, evidenced by glyoxylic acid staining and the expression of tyrosine hydroxylase (TH) and nerve peptide Y (NPY).
Thus, 6-OHDA is promising as an ideal reagent for the local denervation of sympathetic nerve from artery system.
American Psychological Association (APA)
Jin, Yufei& Fan, Jun-jun& Li, Fuhang& Bi, Long& Pei, Guo-Xian. 2014. Local Sympathetic Denervation of Femoral Artery in a Rabbit Model by Using 6-Hydroxydopamine In Situ. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-505336
Modern Language Association (MLA)
Jin, Yufei…[et al.]. Local Sympathetic Denervation of Femoral Artery in a Rabbit Model by Using 6-Hydroxydopamine In Situ. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-505336
American Medical Association (AMA)
Jin, Yufei& Fan, Jun-jun& Li, Fuhang& Bi, Long& Pei, Guo-Xian. Local Sympathetic Denervation of Femoral Artery in a Rabbit Model by Using 6-Hydroxydopamine In Situ. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-505336
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505336