Cholecystokinin and Somatostatin Negatively Affect Growth of the Somatostatin-RIN-14B Cells
Joint Authors
El-Kouhen, Karim
Morisset, Jean
Source
International Journal of Endocrinology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-12-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
With the exclusive presence of the pancreatic CCK-2 receptors on the pancreatic delta cells of six different species, this study was undertaken to determine the role of cholecystokinin and gastrin on growth of these somatostatin (SS) cells.
For this study, the SS-RIN-14B cells were used in culture and their growth was evaluated by cell counting.
Results.
To our surprise, we established by Western blot that these RIN cells possess the two CCK receptor subtypes, CCK-1 and CCK-2.
Occupation of the CCK-1 receptors by caerulein, a CCK analog, led to inhibition of cell proliferation, an effect prevented by a specific CCK-1 receptor antagonist.
Occupation of the CCK-2 receptors by the gastrin agonist pentagastrin had no effect on cell growth.
Proliferation was not affected by SS released from these cells but was inhibited by exogenous SS.
Conclusions.
Growth of the SS-RIN-14B cells can be negatively affected by occupation of their CCK-1 receptors and by exogenous somatostatin.
American Psychological Association (APA)
El-Kouhen, Karim& Morisset, Jean. 2008. Cholecystokinin and Somatostatin Negatively Affect Growth of the Somatostatin-RIN-14B Cells. International Journal of Endocrinology،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-505359
Modern Language Association (MLA)
El-Kouhen, Karim& Morisset, Jean. Cholecystokinin and Somatostatin Negatively Affect Growth of the Somatostatin-RIN-14B Cells. International Journal of Endocrinology No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-505359
American Medical Association (AMA)
El-Kouhen, Karim& Morisset, Jean. Cholecystokinin and Somatostatin Negatively Affect Growth of the Somatostatin-RIN-14B Cells. International Journal of Endocrinology. 2008. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-505359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505359