Butylidenephthalide Blocks Potassium Channels and Enhances Basal Tension in Isolated Guinea-Pig Trachea
Joint Authors
Hsu, Hsin-Te
Chen, Chi-Ming
Yang, You-Lan
Ko, Wun-Chang
Chen, Wan-Chen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Butylidenephthalide (Bdph, 30~300 μM), a constituent of Ligusticum chuanxiong Hort., significantly enhanced tension in isolated guinea-pig trachea.
In this study, we investigate the mechanism(s) of Bdph-induced contraction in the tissue.
Isolated trachea was bathed in 5 mL of Krebs solution containing indomethacin (3 μM), and its tension changes were isometrically recorded.
Cromakalim (3 μM), an ATP-dependent K+ channel opener, significantly antagonized the Bdph-induced enhancement of baseline tension.
Bdph (300 μM) also significantly antagonized cromakalim-induced relaxation.
Bdph (300 μM) did not significantly influence the antagonistic effects of glibenclamide (GBC, 1 μM) and tetraethylammonium (TEA, 8 mM) against the cromakalim-induced relaxation.
However, Bdph (300 μM) and 4-aminopiridine (4-AP, 5 mM), a blocker of Kv1 family of K+ channels, in combination significantly rightward shifted the log concentration-relaxation curve of cromakalim.
The antagonistic effect of the combination almost equals the sum of the individual effects of Bdph and 4-AP, suggesting that the antagonistic mechanism of Bdph may be similar to that of 4-AP.
All calcium channel blockers influenced neither the baseline tension nor antagonistic effect of Bdph against cromakalim.
In conclusion, Bdph may be similar to 4-AP, a blocker of Kv1 family of K+ channels, to enhance the baseline tension of guinea-pig trachea.
American Psychological Association (APA)
Hsu, Hsin-Te& Yang, You-Lan& Chen, Wan-Chen& Chen, Chi-Ming& Ko, Wun-Chang. 2014. Butylidenephthalide Blocks Potassium Channels and Enhances Basal Tension in Isolated Guinea-Pig Trachea. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-505363
Modern Language Association (MLA)
Hsu, Hsin-Te…[et al.]. Butylidenephthalide Blocks Potassium Channels and Enhances Basal Tension in Isolated Guinea-Pig Trachea. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-505363
American Medical Association (AMA)
Hsu, Hsin-Te& Yang, You-Lan& Chen, Wan-Chen& Chen, Chi-Ming& Ko, Wun-Chang. Butylidenephthalide Blocks Potassium Channels and Enhances Basal Tension in Isolated Guinea-Pig Trachea. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-505363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505363