Hypoglycemic and Hepatoprotective Activity of Fermented Fruit Juice of Morinda citrifolia (Noni) in Diabetic Rats
Joint Authors
Adogwa, Andrew
Isitor, Godwin
Nayak, B. Shivananda
Marshall, Julien R.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Morinda citrifolia is a medicinal plant used to treat diabetes and liver diseases.
The fermented fruit juice of the M.
Citrifolia (optical density = 1.25) was used to study the hypoglycemic and hepatoprotective properties in diabetes-induced rats.
The rats were randomly distributed into 4 groups (control, diabetic experimental, diabetic standard, and diabetic untreated) of 6 each.
Diabetes was induced by administering Streptozotocin (50 mg/kg body weight).
Fasting blood glucose, body mass, liver tissue glycogen content, and the extent of liver degeneration were assessed.
Diabetic experimental animals were treated with M.
citrifolia juice (2 ml/kg, twice a day) and diabetic standard with reference hypoglycemic drug, glibenclamide orally for 20 days.
Both the groups exhibited a significant reduction in blood glucose level of 150 mg/dl ±15.88 and 125 mg/dl ±3.89, respectively, as compared to diabetic untreated with FBS = 360.0 mg/dl ±15.81, (P<.003).
On 10th day of experiment, diabetic experimental animals exhibited a decrease in body mass (10.2 g, 5.11%) which increased significantly by the 20th day (6 g, 3.0%, P<.022).
Histological study of liver tissue obtained from untreated diabetic animals revealed significant fatty degeneration as compared to other three groups.
The data of this study proved the hypoglycemic and hepatoprotective activity of M.
citrifolia.
American Psychological Association (APA)
Nayak, B. Shivananda& Marshall, Julien R.& Isitor, Godwin& Adogwa, Andrew. 2010. Hypoglycemic and Hepatoprotective Activity of Fermented Fruit Juice of Morinda citrifolia (Noni) in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-505370
Modern Language Association (MLA)
Nayak, B. Shivananda…[et al.]. Hypoglycemic and Hepatoprotective Activity of Fermented Fruit Juice of Morinda citrifolia (Noni) in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-505370
American Medical Association (AMA)
Nayak, B. Shivananda& Marshall, Julien R.& Isitor, Godwin& Adogwa, Andrew. Hypoglycemic and Hepatoprotective Activity of Fermented Fruit Juice of Morinda citrifolia (Noni) in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-505370
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505370