Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases
Joint Authors
Buenrostro, Denise
Sterling, Julie A.
Park, Serk In
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Tumor-induced bone disease is a dynamic process that involves interactions with many cell types.
Once metastatic cancer cells reach the bone, they are in contact with many different cell types that are present in the cell-rich bone marrow.
These cells include the immune cells, myeloid cells, fibroblasts, osteoblasts, osteoclasts, and mesenchymal stem cells.
Each of these cell populations can influence the behavior or gene expression of both the tumor cells and the bone microenvironment.
Additionally, the tumor itself can alter the behavior of these bone marrow cells which further alters both the microenvironment and the tumor cells.
While many groups focus on studying these interactions, much remains unknown.
A better understanding of the interactions between the tumor cells and the bone microenvironment will improve our knowledge on how tumors establish in bone and may lead to improvements in diagnosing and treating bone metastases.
This review details our current knowledge on the interactions between tumor cells that reside in bone and their microenvironment.
American Psychological Association (APA)
Buenrostro, Denise& Park, Serk In& Sterling, Julie A.. 2014. Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-505372
Modern Language Association (MLA)
Buenrostro, Denise…[et al.]. Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-505372
American Medical Association (AMA)
Buenrostro, Denise& Park, Serk In& Sterling, Julie A.. Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-505372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505372