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Correlations between Hippocampal Neurogenesis and Metabolic Indices in Adult Nonhuman Primates
Joint Authors
Yaretskiy, Arkadiy
Kral, John G.
Perera, Tarique D.
Smith, Eric L. P.
Rosenblum, Leonard A.
Thirumangalakudi, Lakshmi
Coplan, Jeremy D.
Lu, Dunyue
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Increased neurogenesis in feeding centers of the murine hypothalamus is associated with weight loss in diet-induced obese rodents (Kokoeva et al., 2005 and Matrisciano et al., 2010), but this relationship has not been examined in other species.
Postmortem hippocampal neurogenesis rates and premortem metabolic parameters were statistically analyzed in 8 chow-fed colony-reared adult bonnet macaques.
Dentate gyrus neurogenesis, reflected by the immature neuronal marker, doublecortin (DCX), and expression of the antiapoptotic gene factor, B-cell lymphoma 2 (BCL-2), but not the precursor proliferation mitotic marker, Ki67, was inversely correlated with body weight and crown-rump length.
DCX and BCL-2 each correlated positively with blood glucose level and lipid ratio (total cholesterol/high-density lipoprotein).
This study demonstrates that markers of dentate gyrus neuroplasticity correlate with metabolic parameters in primates.
American Psychological Association (APA)
Perera, Tarique D.& Lu, Dunyue& Thirumangalakudi, Lakshmi& Smith, Eric L. P.& Yaretskiy, Arkadiy& Rosenblum, Leonard A.…[et al.]. 2011. Correlations between Hippocampal Neurogenesis and Metabolic Indices in Adult Nonhuman Primates. Neural Plasticity،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-505373
Modern Language Association (MLA)
Perera, Tarique D.…[et al.]. Correlations between Hippocampal Neurogenesis and Metabolic Indices in Adult Nonhuman Primates. Neural Plasticity No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-505373
American Medical Association (AMA)
Perera, Tarique D.& Lu, Dunyue& Thirumangalakudi, Lakshmi& Smith, Eric L. P.& Yaretskiy, Arkadiy& Rosenblum, Leonard A.…[et al.]. Correlations between Hippocampal Neurogenesis and Metabolic Indices in Adult Nonhuman Primates. Neural Plasticity. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-505373
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505373