Does Loop Electrosurgical Excision Procedure of the Uterine Cervix Affect Anti-Müllerian Hormone Levels?
Joint Authors
Sklavos, Martha M.
Pinto, Ligia A.
Saftlas, Audrey F.
Spracklen, Cassandra N.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
A delayed time to pregnancy was recently reported for women who had a loop electrosurgical excision procedure (LEEP) to remove cervical intraepithelial neoplasia (CIN) grade 2 or 3.
The objective of the current study was to determine if treatment of CIN with LEEP is associated with decreased levels of anti-Müllerian hormone (AMH), a marker of ovarian reserve.
Methods.
AMH levels were measured in 18 women treated with LEEP and 18 age-matched controls, who had colposcopy only and did not require LEEP.
Cases and controls had their blood drawn at study entry time zero and again 6 months later.
Results.
The mean AMH level decreased significantly from baseline to follow-up; however, no significant differences were observed when stratifying by LEEP status, suggesting that both groups experienced a similar decrease in AMH levels during the follow-up period.
Although women treated with LEEP had lower overall AMH levels than controls at both baseline and follow-up, these differences were not statistically significant.
Conclusion.
Overall, the delayed time to pregnancy observed in women treated with LEEP is likely not due to a LEEP-associated decrease in ovarian reserve as measured by AMH; thus, other mechanism are responsible for the delayed time to pregnancy associated with LEEP.
American Psychological Association (APA)
Sklavos, Martha M.& Spracklen, Cassandra N.& Saftlas, Audrey F.& Pinto, Ligia A.. 2014. Does Loop Electrosurgical Excision Procedure of the Uterine Cervix Affect Anti-Müllerian Hormone Levels?. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-505393
Modern Language Association (MLA)
Sklavos, Martha M.…[et al.]. Does Loop Electrosurgical Excision Procedure of the Uterine Cervix Affect Anti-Müllerian Hormone Levels?. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-505393
American Medical Association (AMA)
Sklavos, Martha M.& Spracklen, Cassandra N.& Saftlas, Audrey F.& Pinto, Ligia A.. Does Loop Electrosurgical Excision Procedure of the Uterine Cervix Affect Anti-Müllerian Hormone Levels?. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-505393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505393