Blood Level Omega-3 Fatty Acids as Risk Determinant Molecular Biomarker for Prostate Cancer
Joint Authors
Morales, Marcelino
Chua, Michael E.
Sio, Maria Christina D.
Sorongon-Legaspi, Mishell Kris
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-25
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Previous researches involving dietary methods have shown conflicting findings.
Authors sought to assess the association of prostate cancer risk with blood levels of omega-3 polyunsaturated fatty acids (n-3 PUFA) through a meta-analysis of human epidemiological studies in available online databases (July, 2012).
After critical appraisal by two independent reviewers, Newcastle-Ottawa Quality Assessment Scale (NOQAS) was used to grade the studies.
Six case control and six nested case control studies were included.
Results showed nonsignificant association of overall effect estimates with total or advanced prostate cancer or high-grade tumor.
High blood level of alpha-linolenic acid (ALA) had nonsignificant positive association with total prostate cancer risk.
High blood level of docosapentaenoic acid (DPA) had significant negative association with total prostate cancer risk.
Specific n-3 PUFA in fish oil, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) had positive association with high-grade prostate tumor risk only after adjustment of interstudy variability.
There is evidence that high blood level of DPA that is linked with reduced total prostate cancer risk and elevated blood levels of fish oils, EPA, and DHA is associated with high-grade prostate tumor, but careful interpretation is needed due to intricate details involved in prostate carcinogenesis and N-3 PUFA metabolism.
American Psychological Association (APA)
Sorongon-Legaspi, Mishell Kris& Chua, Michael E.& Sio, Maria Christina D.& Morales, Marcelino. 2013. Blood Level Omega-3 Fatty Acids as Risk Determinant Molecular Biomarker for Prostate Cancer. Prostate Cancer،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-505401
Modern Language Association (MLA)
Sorongon-Legaspi, Mishell Kris…[et al.]. Blood Level Omega-3 Fatty Acids as Risk Determinant Molecular Biomarker for Prostate Cancer. Prostate Cancer No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-505401
American Medical Association (AMA)
Sorongon-Legaspi, Mishell Kris& Chua, Michael E.& Sio, Maria Christina D.& Morales, Marcelino. Blood Level Omega-3 Fatty Acids as Risk Determinant Molecular Biomarker for Prostate Cancer. Prostate Cancer. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-505401
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505401