Differential Expression of Matrix Metalloproteases in Human Fibroblasts with Different Origins
Joint Authors
Becher, P. Moritz
Lindner, Diana
Schultheiss, Heinz-Peter
Tschöpe, Carsten
Zietsch, Christin
Westermann, Dirk
Schulze, Karsten
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Fibroblasts are widely distributed cells and are responsible for the deposition of extracellular matrix (ECM) components but also secrete ECM-degrading matrix metalloproteases.
A finely balanced equilibrium between deposition and degradation of ECM is essential for structural integrity of tissues.
In the past, fibroblasts have typically been understood as a uniform cell population with comparable functions regardless of their origin.
Here, we determined growth curves of fibroblasts derived from heart, skin, and lung and clearly show the lowest proliferation rate for cardiac fibroblasts.
Furthermore, we examined basal expression levels of collagen and different MMPs in these three types of fibroblasts and compared these concerning their site of origin.
Interestingly, we found major differences in basal mRNA expression especially for MMP1 and MMP3.
Moreover, we treated fibroblasts with TNF-α and observed different alterations under these proinflammatory conditions.
In conclusion, fibroblasts show different properties in proliferation and MMP expression regarding their originated tissue.
American Psychological Association (APA)
Lindner, Diana& Zietsch, Christin& Becher, P. Moritz& Schulze, Karsten& Schultheiss, Heinz-Peter& Tschöpe, Carsten…[et al.]. 2012. Differential Expression of Matrix Metalloproteases in Human Fibroblasts with Different Origins. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-505412
Modern Language Association (MLA)
Lindner, Diana…[et al.]. Differential Expression of Matrix Metalloproteases in Human Fibroblasts with Different Origins. Biochemistry Research International No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-505412
American Medical Association (AMA)
Lindner, Diana& Zietsch, Christin& Becher, P. Moritz& Schulze, Karsten& Schultheiss, Heinz-Peter& Tschöpe, Carsten…[et al.]. Differential Expression of Matrix Metalloproteases in Human Fibroblasts with Different Origins. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-505412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505412