Angiotensinogen Gene Transcription in Pulmonary Fibrosis
Joint Authors
Uhal, Bruce D.
Dang, My-Trang T.
Li, Xiaopeng
Abdul-Hafez, Amal
Source
International Journal of Peptides
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
An established body of literature supports the hypothesis that activation of a local tissue angiotensin (ANG) system in the extravascular tissue compartment of the lungs is required for lung fibrogenesis.
Transcriptional activation of the angiotensinogen (AGT) gene is believed to be a critical and necessary step in this activation.
This paper summarizes the data in support of this theory and discusses transcriptional regulation of AGT, with an emphasis on lung AGT synthesis as a determinant of fibrosis severity.
Genetic data linking AGT polymorphisms to the severity of disease in Idiopathic Pulmonary Fibrosis are also discussed.
American Psychological Association (APA)
Uhal, Bruce D.& Dang, My-Trang T.& Li, Xiaopeng& Abdul-Hafez, Amal. 2012. Angiotensinogen Gene Transcription in Pulmonary Fibrosis. International Journal of Peptides،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-505431
Modern Language Association (MLA)
Uhal, Bruce D.…[et al.]. Angiotensinogen Gene Transcription in Pulmonary Fibrosis. International Journal of Peptides No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-505431
American Medical Association (AMA)
Uhal, Bruce D.& Dang, My-Trang T.& Li, Xiaopeng& Abdul-Hafez, Amal. Angiotensinogen Gene Transcription in Pulmonary Fibrosis. International Journal of Peptides. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-505431
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505431