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Characterization of Arterial Wave Reflection in Healthy Bonnet Macaques : Feasibility of Applanation Tonometry
Joint Authors
Salciccioli, Louis
Qureshi, Ghazanfar
Kamran, Haroon
Lazar, Jason M.
Kral, John G.
Rosenblum, Leonard A.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-03-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Nonhuman primates are commonly used in cardiovascular research.
Increased arterial stiffness is a marker of subclinical atherosclerosis and higher CV risk.
We determined the augmentation index (AI) using applanation tonometry in 61 healthy monkeys (59% female, age 1–25 years).
Technically adequate studies were obtained in all subjects and required 1.5±1.3 minutes.
The brachial artery provided the highest yield (95%).
AI was correlated with heart rate (HR) (r=−0.65, P<.001), crown rump length (CRL) (r = 0.42, P = .001), and left ventricular (LV) mass determined using echocardiography (r=0.52, P<.001).
On multivariate analysis, HR (P<.001) and CRL (P = .005) were independent predictors of AI (R2=0.46, P<.001).
Body Mass Index (BMI) and AI were independent predictors of higher LV mass on multivariate analysis (P<.001 and P=.03).
In conclusion, applanation tonometry is feasible for determining AI.
Reference values are provided for AI in bonnet macaques, in whom higher AI is related to HR and CRL, and in turn contributes to higher LV mass.
American Psychological Association (APA)
Lazar, Jason M.& Qureshi, Ghazanfar& Kamran, Haroon& Rosenblum, Leonard A.& Kral, John G.& Salciccioli, Louis. 2009. Characterization of Arterial Wave Reflection in Healthy Bonnet Macaques : Feasibility of Applanation Tonometry. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-505455
Modern Language Association (MLA)
Lazar, Jason M.…[et al.]. Characterization of Arterial Wave Reflection in Healthy Bonnet Macaques : Feasibility of Applanation Tonometry. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-505455
American Medical Association (AMA)
Lazar, Jason M.& Qureshi, Ghazanfar& Kamran, Haroon& Rosenblum, Leonard A.& Kral, John G.& Salciccioli, Louis. Characterization of Arterial Wave Reflection in Healthy Bonnet Macaques : Feasibility of Applanation Tonometry. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-505455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505455