Redundant Vasodilator Pathways Underlying Radial Artery Flow-Mediated Dilation Are Preserved in Healthy Aging
Joint Authors
Zaleski, Amanda L.
Tschakovsky, Michael E.
Thompson, Paul D.
Kiernan, Francis J.
Ballard, Kevin D.
Polk, Donna M.
Parker, Beth A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background.
Blocking nitric oxide (NO) and vasodilator prostanoids (PN) does not consistently reduce flow-mediated dilation (FMD) in young adults.
The impact of aging on the contribution of NO and PG to FMD is unknown.
Methods.
FMD was measured in older adults (n=10, 65±3 y) after arterial infusion of saline, N(G)-monomethyl-L-arginine (L-NMMA), and ketorolac + L-NMMA.
Data were compared to published data in young adults.
Results.
L-NMMA reduced FMD in older adults (8.9±3.6 to 5.9±3.7%) although this was not statistically significant (P=0.08) and did not differ (P=0.74) from the reduction observed in young adults (10.0±3.8 to 7.6±4.7%; P=0.03).
Blocking PN did not affect FMD in young or older adults.
In older adults, L-NMMA reduced (n=6; range = 36–123% decrease), augmented (n=3; 10–122% increase), or did not change FMD (n=1; 0.4% increase).
After PN blockade, FMD responses were reduced (n=2), augmented (n=6), or unaffected (n=1).
Conclusions.
NO or PN blockade did not consistently reduce FMD in healthy older adults, suggesting the existence of redundant vasodilator phenotypes as observed previously in young adults.
American Psychological Association (APA)
Ballard, Kevin D.& Tschakovsky, Michael E.& Zaleski, Amanda L.& Polk, Donna M.& Thompson, Paul D.& Kiernan, Francis J.…[et al.]. 2014. Redundant Vasodilator Pathways Underlying Radial Artery Flow-Mediated Dilation Are Preserved in Healthy Aging. Journal of Aging Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-505459
Modern Language Association (MLA)
Ballard, Kevin D.…[et al.]. Redundant Vasodilator Pathways Underlying Radial Artery Flow-Mediated Dilation Are Preserved in Healthy Aging. Journal of Aging Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-505459
American Medical Association (AMA)
Ballard, Kevin D.& Tschakovsky, Michael E.& Zaleski, Amanda L.& Polk, Donna M.& Thompson, Paul D.& Kiernan, Francis J.…[et al.]. Redundant Vasodilator Pathways Underlying Radial Artery Flow-Mediated Dilation Are Preserved in Healthy Aging. Journal of Aging Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-505459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505459