Pathogenetic role of erythrocyte complement-receptor-1 [CR1] and L-selectin in SLE patients

Abstract EN

Aim of Work : To evaluate the role of erythrocyte CR1 and L-selectin in the pathogenesis of SLE and try to find out any correlation between them with some clinical and laboratory associated data.

Materials and Methods : Thirty patients diagnosed as SLE according to ACR criteria with mean age 23.6 ? 6.9 in addition to 10 apparently healthy normal (age & sex matched) subjects as a control group were included in this study.

Results : There were higher values of erythrocyte CR1 percentage in controls more than patients (p < 0.05), while this could not be found as regards level of L-selectin (p > 0.05).

A significant association was found between erythrocyte CR1 percentage with fever and arthralgia (p < 0.05), but this could not be found as regards the other clinical findings.

There was a significant association between the level of L-selectin with arthralgia and cardiac affection (p < 0.05), but this was not found with other clinical findings.

Significant correlations were found between erythrocyte CR1 percentage and serum creatinine level, urinary pus cells ESR and platelets counts (p < 0.05), while no correlations were found between L-selectin level and other laboratory findings.

No correlations were found between erythrocyte CR1 percentage and L-selectin level with disease onset, duration or disease activity score.

Conclusion : Both erythrocytes CR1 and L-selectin (to a lesser extent) have a crucial role in the pathogenesis of SLE as regards joint and kidney affection through IC mediated vacuities.