Comparison of the Genetic Organization, Expression Strategies and Oncogenic Potential of HTLV-1 and HTLV-2
Joint Authors
Ciminale, Vincenzo
Diani, Erica
Bertazzoni, Umberto
Rende, Francesca
Cavallari, Ilaria
Romanelli, Maria Grazia
Source
Leukemia Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-29
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Mechanical Engineering
Medicine
Abstract EN
Human T cell leukemia virus types 1 and 2 (HTLV-1 and HTLV-2) are genetically related complex retroviruses that are capable of immortalizing human T-cells in vitro and establish life-long persistent infections in vivo.
In spite of these apparent similarities, HTLV-1 and HTLV-2 exhibit a significantly different pathogenic potential.
HTLV-1 is recognized as the causative agent of adult T-cell leukemia/lymphoma (ATLL) and tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM).
In contrast, HTLV-2 has not been causally linked to human malignancy, although it may increase the risk of developing inflammatory neuropathies and infectious diseases.
The present paper is focused on the studies aimed at defining the viral genetic determinants of the pathobiology of HTLV-1 and HTLV-2 through a comparison of the expression strategies and functional properties of the different gene products of the two viruses.
American Psychological Association (APA)
Rende, Francesca& Cavallari, Ilaria& Romanelli, Maria Grazia& Diani, Erica& Bertazzoni, Umberto& Ciminale, Vincenzo. 2011. Comparison of the Genetic Organization, Expression Strategies and Oncogenic Potential of HTLV-1 and HTLV-2. Leukemia Research and Treatment،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-505463
Modern Language Association (MLA)
Rende, Francesca…[et al.]. Comparison of the Genetic Organization, Expression Strategies and Oncogenic Potential of HTLV-1 and HTLV-2. Leukemia Research and Treatment No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-505463
American Medical Association (AMA)
Rende, Francesca& Cavallari, Ilaria& Romanelli, Maria Grazia& Diani, Erica& Bertazzoni, Umberto& Ciminale, Vincenzo. Comparison of the Genetic Organization, Expression Strategies and Oncogenic Potential of HTLV-1 and HTLV-2. Leukemia Research and Treatment. 2011. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-505463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505463