Cardiovascular Activity of Labdane Diterpenes from Andrographis paniculata in Isolated Rat Hearts
Joint Authors
Su Fong, Yew
Abdullah, Nor Hayati
Hadi, A. Hamid A.
Awang, Khalijah
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity.
The extract significantly reduced coronary perfusion pressure by up to 24.5±3.0 mm Hg at a 3 mg dose and also reduced heart rate by up to 49.5±11.4 beats/minute at this dose.
Five labdane diterpenes, 14-deoxy-12-hydroxyandrographolide (1), 14-deoxy-11,12-didehydroandrographolide (2), 14-deoxyandrographolide (3), andrographolide (4), and neoandrographolide (5), were isolated from the aerial parts of this medicinal plant.
Bioassay-guided studies using animal model showed that compounds, (2) and (3) were responsible for the coronary vasodilatation.
This study also showed that andrographolide (4), the major labdane diterpene in this plant, has minimal effects on the heart.
American Psychological Association (APA)
Awang, Khalijah& Abdullah, Nor Hayati& Hadi, A. Hamid A.& Su Fong, Yew. 2012. Cardiovascular Activity of Labdane Diterpenes from Andrographis paniculata in Isolated Rat Hearts. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-505497
Modern Language Association (MLA)
Awang, Khalijah…[et al.]. Cardiovascular Activity of Labdane Diterpenes from Andrographis paniculata in Isolated Rat Hearts. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-505497
American Medical Association (AMA)
Awang, Khalijah& Abdullah, Nor Hayati& Hadi, A. Hamid A.& Su Fong, Yew. Cardiovascular Activity of Labdane Diterpenes from Andrographis paniculata in Isolated Rat Hearts. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-505497
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505497