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Deletion of the Men1 Gene Prevents Streptozotocin-Induced Hyperglycemia in Mice
Joint Authors
Wang, Haoren
Hua, Xianxin
Yang, Yuqing
Source
Experimental Diabetes Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Diabetes ultimately results from an inadequate number of functional beta cells in the islets of Langerhans.
Enhancing proliferation of functional endogenous beta cells to treat diabetes remains underexplored.
Here, we report that excision of the Men1 gene, whose loss-of-function mutation leads to inherited multiple endocrine neoplasia type 1 (MEN1), rendered resistant to streptozotocin-induced hyperglycemia in a tamoxifen-inducible and temporally controlled Men1 excision mouse model as well as in a tissue-specific Men1 excision mouse model.
Men1 excision prevented mice from streptozotocin-induced hyperglycemia mainly through increasing the number of functional beta cells.
BrdU incorporation by beta cells, islet size, and circulating insulin levels were significantly increased in Men1-excised mice.
Membrane localization of glucose transporter 2 was largely preserved in Men1-excised beta cells, but not in Men1-expressing beta cells.
Our findings suggest that repression of menin, a protein encoded by the Men1 gene, might be a valuable means to maintain or increase the number of functional endogenous beta cells to prevent or ameliorate diabetes.
American Psychological Association (APA)
Yang, Yuqing& Wang, Haoren& Hua, Xianxin. 2011. Deletion of the Men1 Gene Prevents Streptozotocin-Induced Hyperglycemia in Mice. Experimental Diabetes Research،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-505509
Modern Language Association (MLA)
Yang, Yuqing…[et al.]. Deletion of the Men1 Gene Prevents Streptozotocin-Induced Hyperglycemia in Mice. Experimental Diabetes Research No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-505509
American Medical Association (AMA)
Yang, Yuqing& Wang, Haoren& Hua, Xianxin. Deletion of the Men1 Gene Prevents Streptozotocin-Induced Hyperglycemia in Mice. Experimental Diabetes Research. 2011. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-505509
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505509