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Nrf2ARE Signaling Pathway : Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS
Joint Authors
Petri, Susanne
Körner, Sonja
Kiaei, Mahmoud
Source
Neurology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Nrf2 (nuclear erythroid 2-related factor 2) is a basic region leucine-zipper transcription factor which binds to the antioxidant response element (ARE) and thereby regulates the expression of a large battery of genes involved in the cellular antioxidant and anti-inflammatory defence as well as mitochondrial protection.
As oxidative stress, inflammation and mitochondrial dysfunctions have been identified as important pathomechanisms in amyotrophic lateral sclerosis (ALS), this signaling cascade has gained interest both with respect to ALS pathogenesis and therapy.
Nrf2 and Keap1 expressions are reduced in motor neurons in postmortem ALS tissue.
Nrf2-activating compounds have shown therapeutic efficacy in the ALS mouse model and other neurodegenerative disease models.
Alterations in Nrf2 and Keap1 expression and dysregulation of the Nrf2/ARE signalling program could contribute to the chronic motor neuron degeneration in ALS and other neurodegenerative diseases.
Therefore, Nrf2 emerges as a key neuroprotective molecule in neurodegenerative diseases.
Our recent studies strongly support that the Nrf2/ARE signalling pathway is an important mediator of neuroprotection and therefore represents a promising target for development of novel therapies against ALS, Parkinson’s disease (PD), Huntington’s disease (HD), and Alzheimer’s disease (AD).
American Psychological Association (APA)
Petri, Susanne& Körner, Sonja& Kiaei, Mahmoud. 2012. Nrf2ARE Signaling Pathway : Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS. Neurology Research International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-505537
Modern Language Association (MLA)
Petri, Susanne…[et al.]. Nrf2ARE Signaling Pathway : Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS. Neurology Research International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-505537
American Medical Association (AMA)
Petri, Susanne& Körner, Sonja& Kiaei, Mahmoud. Nrf2ARE Signaling Pathway : Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS. Neurology Research International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-505537
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505537