Intravenous Iron Repletion Does Not Significantly Decrease Platelet Counts in CKD Patients with Iron Deficiency Anemia
Joint Authors
Gascoyne, Rebecca
Turley, Steven
Dossabhoy, Neville R.
Source
International Journal of Nephrology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-12
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Purpose.
We sought to investigate the effect of IV iron repletion on platelet (PLT) counts in CKD patients with iron deficiency anemia (IDA).
Methods.
We conducted a retrospective chart review, including all patients with CKD and IDA who were treated with iron dextran total dose infusion (TDI) between 2002 and 2007.
Patient demographics were noted, and laboratory values for creatinine, hemoglobin (Hgb), iron stores and PLT were recorded pre- and post-dose.
Results.
153 patients received a total of 251 doses of TDI (mean ± SD = 971 ± 175 mg); age 69±12 years and Creatinine 3.3±1.9 mg/dL.
All CKD stages were represented (stage 4 commonest).
Hgb and Fe stores improved post-TDI (P≪0.001).
There was a very mild decrease in PLT (pre-TDI 255 versus post-TDI 244, P=0.30).
The mild reduction in PLT after TDI remained non-significant (P>0.05) when data was stratified by molecular weight (MW) of iron dextran used (low versus high), as well as by dose administered (<1000 versus ≥1000 mg).
Linear regression analysis between pre-dose PLT and Tsat and Fe showed R2 of 0.01 and 0.04, respectively.
Conclusion.
Correction of iron deficiency did not significantly lower PLT in CKD patients, regardless of MW or dose used.
Correlation of PLT to severity of iron deficiency was very weak.
American Psychological Association (APA)
Dossabhoy, Neville R.& Gascoyne, Rebecca& Turley, Steven. 2013. Intravenous Iron Repletion Does Not Significantly Decrease Platelet Counts in CKD Patients with Iron Deficiency Anemia. International Journal of Nephrology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-505539
Modern Language Association (MLA)
Dossabhoy, Neville R.…[et al.]. Intravenous Iron Repletion Does Not Significantly Decrease Platelet Counts in CKD Patients with Iron Deficiency Anemia. International Journal of Nephrology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-505539
American Medical Association (AMA)
Dossabhoy, Neville R.& Gascoyne, Rebecca& Turley, Steven. Intravenous Iron Repletion Does Not Significantly Decrease Platelet Counts in CKD Patients with Iron Deficiency Anemia. International Journal of Nephrology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-505539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505539