New Agents Targeting Angiogenesis in Glioblastoma
Author
Source
Chemotherapy Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Glioblastoma is the most common malignant glioma in adults, and despite recent advances in standard treatment, the prognosis still remains dismal, with a median survival of 15 months.
The incorporation of bevacizumab in the standard treatment of relapsed glioblastoma has been a significant step towards combining targeted agents with chemotherapy, and there is an increasing number of new antiangiogenic agents in various stages of development, that are being tested both in relapsed and newly diagnosed disease, alone or in combination with standard treatment.
The relatively favorable toxicity profile for most of them presents an advantage, but several concerns arise regarding their actual efficacy on the clinical level and the most efficient schedule of administration for each of them, as their molecular targets and patterns of action may vary significantly.
This may lead to future modifications of the current rational of administering these agents concomitantly with initial chemotherapy or maintenance treatment.
American Psychological Association (APA)
Timotheadou, Eleni. 2011. New Agents Targeting Angiogenesis in Glioblastoma. Chemotherapy Research and Practice،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-505597
Modern Language Association (MLA)
Timotheadou, Eleni. New Agents Targeting Angiogenesis in Glioblastoma. Chemotherapy Research and Practice No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-505597
American Medical Association (AMA)
Timotheadou, Eleni. New Agents Targeting Angiogenesis in Glioblastoma. Chemotherapy Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-505597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505597