Vitamin D Pathway Genes, Diet, and Risk of Renal Cell Carcinoma
Joint Authors
Szesznia-Dabrowska, N.
Rothman, N.
Yeager, Meredith
Navratilova, M.
Boffetta, Paolo
Bencko, V.
Chanock, S.
Moore, L. E.
Kollarova, H.
Matveev, V.
Holcatova, I.
Mates, D.
Janout, V.
Zaridze, D.
Karami, S.
Brennan, P.
Chow, W-H.
Source
International Journal of Endocrinology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Mediated by binding to the high-affinity vitamin D receptor (VDR), vitamin D forms a heterodimer complex with the retinoid-X-receptor (RXR).
Variation in both genes has been shown to modify renal cell carcinoma (RCC) risk.
Therefore, we investigated whether VDR and RXRA polymorphisms modify associations between RCC risk and frequency of dietary intake of vitamin D and calcium rich foods, and occupational ultraviolet exposure among 777 RCC case and 1035 controls from Central and Eastern Europe.
A positive association was observed in this population between increasing dietary intake frequency of yogurt, while an inverse association was observed with egg intake frequency.
RXRA polymorphisms, located 3′ of the coding sequence, modified associations between specific vitamin D rich foods and RCC risk, while RXRA polymorphisms, located in introns 1 and 4, modified associations with specific calcium rich foods.
Results suggest that variants in the RXRA gene modified the associations observed between RCC risk and calcium and vitamin D intake.
American Psychological Association (APA)
Karami, S.& Brennan, P.& Navratilova, M.& Mates, D.& Zaridze, D.& Janout, V.…[et al.]. 2009. Vitamin D Pathway Genes, Diet, and Risk of Renal Cell Carcinoma. International Journal of Endocrinology،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-505639
Modern Language Association (MLA)
Karami, S.…[et al.]. Vitamin D Pathway Genes, Diet, and Risk of Renal Cell Carcinoma. International Journal of Endocrinology No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-505639
American Medical Association (AMA)
Karami, S.& Brennan, P.& Navratilova, M.& Mates, D.& Zaridze, D.& Janout, V.…[et al.]. Vitamin D Pathway Genes, Diet, and Risk of Renal Cell Carcinoma. International Journal of Endocrinology. 2009. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-505639
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505639