Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies
Joint Authors
Kasukabe, Takashi
Okabe-Kado, Junko
Kaneko, Yasuhiko
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
An elevated serum level of NM23-H1 protein is a poor prognostic factor in patients with various hematologic malignancies.
The extracellular NM23-H1 protein promotes the in vitro growth and survival of acute myelogenous leukemia (AML) cells and inversely inhibits the in vitro survival of normal peripheral blood monocytes in primary culture at concentrations equivalent to the levels found in the serum of AML patients.
The growth and survival promoting activity to AML cells is associated with cytokine production and activation of mitogen-activated protein kinases (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways.
Inhibitors specific for MAPK signaling pathways inhibit the growth/survival-promoting activity of NM23-H1.
These findings indicate a novel biological action of extracellular NM23-H1 and its association with poor prognosis.
These results suggest an important role of extracellular NM23-H1 in the malignant progression of leukemia and a potential therapeutic target for these malignancies.
American Psychological Association (APA)
Okabe-Kado, Junko& Kasukabe, Takashi& Kaneko, Yasuhiko. 2011. Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies. Advances in Hematology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-505640
Modern Language Association (MLA)
Okabe-Kado, Junko…[et al.]. Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies. Advances in Hematology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-505640
American Medical Association (AMA)
Okabe-Kado, Junko& Kasukabe, Takashi& Kaneko, Yasuhiko. Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies. Advances in Hematology. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-505640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505640