Gene Expression of Leptin and Long Leptin Receptor Isoform in Endometriosis : A Case-Control Study

Abstract EN

In this study, leptin/BMI ratio in serum and peritoneal fluid and gene expression of leptin and long form leptin receptor (OB-RL) were assessed in eutopic and ectopic endometria of women with endometriosis and controls.

Increased serum leptin/BMI ratio was found in endometriosis patients.

Leptin and OB-RL gene expression was significantly higher in ectopic versus eutopic endometrium of patients and controls.

A positive, significant correlation was observed between leptin and OB-RL transcripts in ectopic endometria and also in eutopic endometria in endometriosis and control groups.

A negative and significant correlation was found between OB-RL mRNA expression and peritoneal fluid leptin/BMI ratio only in endometriosis.

These data suggest that, through a modulatory interaction with its active receptor, leptin might play a role in the development of endometrial implants.