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In Situ Absorption in Rat Intestinal Tract of Solid Dispersion of Annonaceous Acetogenins
Joint Authors
Dang, Yun-Jie
Hu, Chun-Hui
Feng, Han-Zhou
Zhang, Limei
Zhu, Chun-Yan
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Isolated from Annona squamosa L, Annonaceous acetogenins (ACGs) exhibit a broad range of biological properties yet absorbed badly due to the low solubility.
Solid dispersion in polyethylene glycol 4000 (PEG 4000) has been developed to increase the solubility and oral absorption of ACGs.
The formulation of ACGS-solid dispersion was optimized by a simplex lattice experiment design and carried out by a solvent-fusion method.
We studied the absorption property of ACGs in rat’s intestine, which showed there was a good absorption and uptake percentages with solid dispersion.
The study on uptake percentage in different regions of rat’s intestine attested that the duodenum had the best permeability, followed by jejunum, ileum, and colon in order with no significant differences.
So the paper drew the conclusion that solid dispersion could improve the solubility and oral absorption of annonaceous acetogenins.
American Psychological Association (APA)
Dang, Yun-Jie& Feng, Han-Zhou& Zhang, Limei& Hu, Chun-Hui& Zhu, Chun-Yan. 2012. In Situ Absorption in Rat Intestinal Tract of Solid Dispersion of Annonaceous Acetogenins. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-505665
Modern Language Association (MLA)
Dang, Yun-Jie…[et al.]. In Situ Absorption in Rat Intestinal Tract of Solid Dispersion of Annonaceous Acetogenins. Gastroenterology Research and Practice No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-505665
American Medical Association (AMA)
Dang, Yun-Jie& Feng, Han-Zhou& Zhang, Limei& Hu, Chun-Hui& Zhu, Chun-Yan. In Situ Absorption in Rat Intestinal Tract of Solid Dispersion of Annonaceous Acetogenins. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-505665
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505665