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7-Tesla Magnetic Resonance Imaging Precisely and Noninvasively Reflects Inflammation and Remodeling of the Skeletal Muscle in a Mouse Model of Antisynthetase Syndrome
Joint Authors
Campana, Lara
Rovere-Querini, Patrizia
Sciorati, Clara
Manfredi, Angelo A.
Del Maschio, Alessandro
De Cobelli, Francesco
Ascheman, Dana P.
Palmisano, Anna
Canu, Tamara
Monno, Antonella
Esposito, Antonio
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Inflammatory myopathies comprise heterogeneous disorders.
Their etiopathogenesis is poorly understood, because of the paucity of informative experimental models and of approaches for the noninvasive study of inflamed tissues.
Magnetic resonance imaging (MRI) provides information about the state of the skeletal muscle that reflects various facets of inflammation and remodeling.
This technique has been scarcely used in experimental models of inflammatory myopathies.
We characterized the performance of MRI in a well-established mouse model of myositis and the antisynthetase syndrome, based on the immunization of wild-type mice with the amino-terminal fragment of histidyl-tRNA synthetase (HisRS).
Over an eight-week period following myositis induction, MRI enabled precise identification of pathological events taking place in muscle tissue.
Areas of edema and of active inflammation identified by histopathology paralleled muscle modifications detected noninvasively by MRI.
Muscles changes were chronologically associated with the establishment of autoimmunity, as reflected by the development of anti-HisRS antibodies in the blood of immunized mice.
MR imaging easily appreciated muscle damage and remodeling even if actual disruption of myofiber integrity (as assessed by serum concentrations of creatinine phosphokinase) was limited.
Thus, MR imaging represents an informative and noninvasive analytical tool for studying in vivo immune-mediated muscle involvement.
American Psychological Association (APA)
Sciorati, Clara& Esposito, Antonio& Campana, Lara& Canu, Tamara& Monno, Antonella& Palmisano, Anna…[et al.]. 2014. 7-Tesla Magnetic Resonance Imaging Precisely and Noninvasively Reflects Inflammation and Remodeling of the Skeletal Muscle in a Mouse Model of Antisynthetase Syndrome. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-505669
Modern Language Association (MLA)
Sciorati, Clara…[et al.]. 7-Tesla Magnetic Resonance Imaging Precisely and Noninvasively Reflects Inflammation and Remodeling of the Skeletal Muscle in a Mouse Model of Antisynthetase Syndrome. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-505669
American Medical Association (AMA)
Sciorati, Clara& Esposito, Antonio& Campana, Lara& Canu, Tamara& Monno, Antonella& Palmisano, Anna…[et al.]. 7-Tesla Magnetic Resonance Imaging Precisely and Noninvasively Reflects Inflammation and Remodeling of the Skeletal Muscle in a Mouse Model of Antisynthetase Syndrome. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-505669
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505669