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Immunolocalization of Kisspeptin Associated with Amyloid-β Deposits in the Pons of an Alzheimer’s Disease Patient
Joint Authors
Ashioti, Maria
Chilumuri, Amrutha
Milton, Nathaniel G. N.
Nercessian, Amanda N.
Source
Journal of Neurodegenerative Diseases
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The pons region of the Alzheimer’s disease (AD) brain is one of the last to show amyloid-β (Aβ) deposits and has been suggested to contain neuroprotective compounds.
Kisspeptin (KP) is a hormone that activates the hypothalamic-pituitary-gonadal axis and has been suggested to be neuroprotective against Aβ toxicity.
The localization of KP, plus the established endogenous neuroprotective compounds corticotropin releasing hormone (CRH) and catalase, in tissue sections from the pons region of a male AD subject has been determined in relation to Aβ deposits.
Results showed Aβ deposits also stained with KP, CRH, and catalase antibodies.
At high magnification the staining of deposits was either KP or catalase positive, and there was only a limited area of the deposits with KP-catalase colocalization.
The CRH does not bind Aβ, whilst both KP and catalase can bind Aβ, suggesting that colocalization in Aβ deposits is not restricted to compounds that directly bind Aβ.
The neuroprotective actions of KP, CRH, and catalase were confirmed in vitro, and fibrillar Aβ preparations were shown to stimulate the release of KP in vitro.
In conclusion, neuroprotective KP, CRH, and catalase all colocalize with Aβ plaque-like deposits in the pons region from a male AD subject.
American Psychological Association (APA)
Chilumuri, Amrutha& Ashioti, Maria& Nercessian, Amanda N.& Milton, Nathaniel G. N.. 2013. Immunolocalization of Kisspeptin Associated with Amyloid-β Deposits in the Pons of an Alzheimer’s Disease Patient. Journal of Neurodegenerative Diseases،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-505670
Modern Language Association (MLA)
Chilumuri, Amrutha…[et al.]. Immunolocalization of Kisspeptin Associated with Amyloid-β Deposits in the Pons of an Alzheimer’s Disease Patient. Journal of Neurodegenerative Diseases No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-505670
American Medical Association (AMA)
Chilumuri, Amrutha& Ashioti, Maria& Nercessian, Amanda N.& Milton, Nathaniel G. N.. Immunolocalization of Kisspeptin Associated with Amyloid-β Deposits in the Pons of an Alzheimer’s Disease Patient. Journal of Neurodegenerative Diseases. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-505670
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505670