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Bee Venom Mitigates Cisplatin-Induced Nephrotoxicity by Regulating CD4+CD25+Foxp3+ Regulatory T Cells in Mice
Joint Authors
Kim, Jong-Yoon
Chung, Hwan-Suck
Lee, Gihyun
Bae, Hyunsu
Park, Soojin
Nam, Sangsoo
Kim, Sun Kwang
Kim, Hyunseong
Lee, Hyojung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cisplatin is used as a potent anticancer drug, but it often causes nephrotoxicity.
Bee venom (BV) has been used for the treatment of various inflammatory diseases, and its renoprotective action was shown in NZB/W mice.
However, little is known about whether BV has beneficial effects on cisplatin-induced nephrotoxicity and how such effects might be mediated.
In the present study, the BV-injected group showed a significant increase in the population of Tregs in spleen.
Although there was no significant difference in the numbers of Tregs 3 days after cisplatin injection between the BV- and PBS-injected groups, more migration of Tregs into the kidney was observed 6 hours after cisplatin administration in BV group than in PBS group.
In addition, BV-injected mice showed reduced levels of serum creatinine, blood urea nitrogen, renal tissue damage, proinflammatory cytokines, and macrophage infiltration into the kidney 3 days after cisplatin administration.
These renoprotective effects were abolished by the depletion of Tregs.
The anticancer effect of repeated administrations of cisplatin was not affected by BV injection.
These results suggest that BV has protective effects on cisplatin-induced nephrotoxicity in mice, at least in part, through the regulation of Tregs without a big influence on the antitumor effects of cisplatin.
American Psychological Association (APA)
Kim, Hyunseong& Lee, Gihyun& Park, Soojin& Chung, Hwan-Suck& Lee, Hyojung& Kim, Jong-Yoon…[et al.]. 2013. Bee Venom Mitigates Cisplatin-Induced Nephrotoxicity by Regulating CD4+CD25+Foxp3+ Regulatory T Cells in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-505683
Modern Language Association (MLA)
Kim, Hyunseong…[et al.]. Bee Venom Mitigates Cisplatin-Induced Nephrotoxicity by Regulating CD4+CD25+Foxp3+ Regulatory T Cells in Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-505683
American Medical Association (AMA)
Kim, Hyunseong& Lee, Gihyun& Park, Soojin& Chung, Hwan-Suck& Lee, Hyojung& Kim, Jong-Yoon…[et al.]. Bee Venom Mitigates Cisplatin-Induced Nephrotoxicity by Regulating CD4+CD25+Foxp3+ Regulatory T Cells in Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-505683
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505683