Cytotoxic Chemotherapy and CD4+ Effector T Cells : An Emerging Alliance for Durable Antitumor Effects
Joint Authors
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Standard cytotoxic chemotherapy can initially achieve high response rates, but relapses often occur in patients and represent a severe clinical problem.
As increasing numbers of chemotherapeutic agents are found to have immunostimulatory effects, there is a growing interest to combine chemotherapy and immunotherapy for synergistic antitumor effects and improved clinical benefits.
Findings from recent studies suggest that highly activated, polyfunctional CD4+ effector T cells have tremendous potential in strengthening and sustaining the overall host antitumor immunity in the postchemotherapy window.
This review focuses on the latest progresses regarding the impact of chemotherapy on CD4+ T-cell phenotype and function and discusses the prospect of exploiting CD4+ T cells to control tumor progression and prevent relapse after chemotherapy.
American Psychological Association (APA)
Ding, Zhi-Chun& Zhou, Gang. 2012. Cytotoxic Chemotherapy and CD4+ Effector T Cells : An Emerging Alliance for Durable Antitumor Effects. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-505692
Modern Language Association (MLA)
Ding, Zhi-Chun& Zhou, Gang. Cytotoxic Chemotherapy and CD4+ Effector T Cells : An Emerging Alliance for Durable Antitumor Effects. Clinical and Developmental Immunology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-505692
American Medical Association (AMA)
Ding, Zhi-Chun& Zhou, Gang. Cytotoxic Chemotherapy and CD4+ Effector T Cells : An Emerging Alliance for Durable Antitumor Effects. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-505692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505692