Estrogen Abolishes Protective Effect of Erythropoietin against Cisplatin-Induced Nephrotoxicity in Ovariectomized Rats
Joint Authors
Ashrafi, Farzaneh
Mansouri, Azam
Talebi, Ardeshir
Nasri, Hamid
Mazaheri, Safoora
Pezeshki, Zahra
Eshraghi-Jazi, Fatemeh
Nematbakhsh, Mehdi
Safari, Tahereh
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Nephrotoxicity is one the side effect of cisplatin therapy and erythropoietin has been candidate as a nephroprotectant agent.
However, its nephroprotective effect when it is accompained with estrogen has not been studied in female.
Methods.
27 ovariectomized female Wistar rats divided into five groups.
Groups 1 & 2 received estradiol valerate (0.5 mg/kg/week) for four weeks, and single dose of cisplatin (7 mg/kg, ip) was administrated at the end of week 3.
Then the group 1 was treated with erythropoietin (100 U/kg/day), and the group 2 received vehicle during week 4.
Groups 3 and 4 were treated similar to group 1 and 2, except for placebo instead estradiol valerate.
Group5 (negative control) received placebo during the study.
Animals were killed at the end of week 4.
Results.
In non-erythropoietin treated rats, cisplatin significantly increased the serum levels of blood urea nitrogen and creatinine (P<0.05).
However, these biomarkers significantly decreased by erythropoietin (P<0.05).
The weight loss, kidney weight, and kidney tissue damage score in rats treated with cisplatin but without estradiol were significantly less than the values in similar group when estradiol was present (P<0.05).
Conclusion.
It seems that erythropoietin could protect the kidney against cisplatin-induced nephrotoxicity.
This protective effect was not observed when estrogen was present.
American Psychological Association (APA)
Pezeshki, Zahra& Nematbakhsh, Mehdi& Mazaheri, Safoora& Eshraghi-Jazi, Fatemeh& Talebi, Ardeshir& Nasri, Hamid…[et al.]. 2012. Estrogen Abolishes Protective Effect of Erythropoietin against Cisplatin-Induced Nephrotoxicity in Ovariectomized Rats. ISRN Oncology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-505710
Modern Language Association (MLA)
Pezeshki, Zahra…[et al.]. Estrogen Abolishes Protective Effect of Erythropoietin against Cisplatin-Induced Nephrotoxicity in Ovariectomized Rats. ISRN Oncology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-505710
American Medical Association (AMA)
Pezeshki, Zahra& Nematbakhsh, Mehdi& Mazaheri, Safoora& Eshraghi-Jazi, Fatemeh& Talebi, Ardeshir& Nasri, Hamid…[et al.]. Estrogen Abolishes Protective Effect of Erythropoietin against Cisplatin-Induced Nephrotoxicity in Ovariectomized Rats. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-505710
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505710