The Association between Survival and the Pathologic Features of Periampullary Tumors Varies over Time
Joint Authors
Fridirici, Zachary
Yong, Sherri
Godambe, Anjali S.
Aranha, Gerard V.
Sinacore, James M.
Abood, Gerard J.
Plichta, Jennifer K.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Introduction.
Several histopathologic features of periampullary tumors have been shown to be correlated with prognosis.
We evaluated their association with mortality at multiple time points.
Methods.
A retrospective chart review identified 207 patients with periampullary adenocarcinomas who underwent pancreaticoduodenectomy between January 1, 2001 and December 31, 2009.
Clinicopathologic features were assessed, and the data were analyzed using univariate and multivariate methods.
Results.
In univariate analysis, perineural invasion had a strong association with 1-year mortality (OR 3.03, CI 1.42–6.47), and one lymph node (LN) increase in the LN ratio (LNR) equated with a 5-fold increase in mortality.
In contrast, LN status (OR 6.42, CI 3.32–12.41) and perineural invasion (OR 5.44, CI 2.81–10.52) had the strongest associations with mortality at 3 years.
Using Cox proportional hazards, perineural invasion (HR 2.61, CI 1.77–3.85) and LN status (HR 2.69, CI 1.84–3.95) had robust associations with overall mortality.
Recursive partitioning analysis identified LNR as the most important risk factor for mortality at 1 and 3 years.
Conclusions.
Overall mortality was closely related to the LNR within the first year, while longer follow-up periods demonstrated a stronger association with perineural invasion and overall LN status.
Therefore, the current staging for periampullary tumors may need to be updated to include the LNR.
American Psychological Association (APA)
Plichta, Jennifer K.& Godambe, Anjali S.& Fridirici, Zachary& Yong, Sherri& Sinacore, James M.& Abood, Gerard J.…[et al.]. 2014. The Association between Survival and the Pathologic Features of Periampullary Tumors Varies over Time. HPB Surgery،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-505734
Modern Language Association (MLA)
Plichta, Jennifer K.…[et al.]. The Association between Survival and the Pathologic Features of Periampullary Tumors Varies over Time. HPB Surgery No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-505734
American Medical Association (AMA)
Plichta, Jennifer K.& Godambe, Anjali S.& Fridirici, Zachary& Yong, Sherri& Sinacore, James M.& Abood, Gerard J.…[et al.]. The Association between Survival and the Pathologic Features of Periampullary Tumors Varies over Time. HPB Surgery. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-505734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505734