Synthesis and Antimicrobial Activities of Some New Heterocyclic Compounds Based on 6-Chloropyridazine-3(2H)‎-thione

Abstract EN

Three tricyclic ring system, pyridazino[6,1-b]quinazolin-10-ones, benzimidazolo-pyridazine thione, and 1,2,4-benzotriazino-pyridazinethione along with imidazo-[1,2-b]-pyridazinethione, 1,2,4-triazolo[4,3-b]pyridazine-thione derivatives were synthesized starting from 6-chloropyridazin3-(2H)-thione.

Some disulfide and sulfide derivatives were also prepared.

The antimicrobial activity of the synthesized compounds was tested.

Some of these compounds possess a highly response against gram-positive and gram-negative bacteria as well as fungi.