Mexican Trypanosoma cruzi (TCI) Strains with Different Degrees of Virulence Induce Diverse Humoral and Cellular Immune Responses in a Murine Experimental Infection Model
Joint Authors
Caballero, M. L.
Sosa, S.
Rico, T.
Espinoza, Bertha
Martínez, Ignacio
Vizcaino-Castillo, A.
Oaxaca, E.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
It is has been shown that the majority of T.
cruzi strains isolated from Mexico belong to the T.
cruzi I (TCI).
The immune response produced in response to Mexican T.
cruzi I strains has not been well characterized.
In this study, two Mexican T.
cruzi I strains were used to infect Balb/c mice.
The Queretaro (TBAR/MX/0000/Queretaro)(Qro) strain resulted in 100% mortality.
In contrast, no mortality was observed in mice infected with the Ninoa (MHOM/MX/1994/Ninoa) strain.
Both strains produced extended lymphocyte infiltrates in cardiac tissue.
Ninoa infection induced a diverse humoral response with a higher variety of immunoglobulin isotypes than were found in Qro-infected mice.
Also, a stronger inflammatory TH1 response, represented by IL-12p40, IFNγ, RANTES, MIG, MIP-1β, and MCP-1 production was observed in Qro-infected mice when compared with Ninoa-infected mice.
We propose that an exacerbated TH1 immune response is a likely cause of pathological damage observed in cardiac tissue and the primary cause of death in Qro-infected mice.
American Psychological Association (APA)
Espinoza, Bertha& Rico, T.& Sosa, S.& Oaxaca, E.& Vizcaino-Castillo, A.& Caballero, M. L.…[et al.]. 2011. Mexican Trypanosoma cruzi (TCI) Strains with Different Degrees of Virulence Induce Diverse Humoral and Cellular Immune Responses in a Murine Experimental Infection Model. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-505750
Modern Language Association (MLA)
Espinoza, Bertha…[et al.]. Mexican Trypanosoma cruzi (TCI) Strains with Different Degrees of Virulence Induce Diverse Humoral and Cellular Immune Responses in a Murine Experimental Infection Model. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-505750
American Medical Association (AMA)
Espinoza, Bertha& Rico, T.& Sosa, S.& Oaxaca, E.& Vizcaino-Castillo, A.& Caballero, M. L.…[et al.]. Mexican Trypanosoma cruzi (TCI) Strains with Different Degrees of Virulence Induce Diverse Humoral and Cellular Immune Responses in a Murine Experimental Infection Model. Journal of Biomedicine and Biotechnology. 2011. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-505750
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505750