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Tirapazamine-Doxorubicin Interaction Referring to Heart Oxidative Stress and Ca2+ Balance Protein Levels
Joint Authors
Burdan, Franciszek
Matysiak, Wlodzimierz
Sliwinska, Justyna
Dawidek-Pietryka, Katarzyna
Dudka, Jaroslaw
Korga, Agnieszka
Mandziuk, Slawomir
Jodlowska-Jedrych, Barbara
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Doxorubicin (DOX) causes long-term cardiomyopathy that is dependent on oxidative stress and contractility disorders.
Tirapazamine (TP), an experimental adjuvant drug, passes the same red-ox transformation as DOX.
The aim of the study was to evaluate an effect of tirapazamine on oxidative stress, contractile protein level, and cardiomyocyte necrosis in rats administered doxorubicin.
Rats were intraperitoneally injected six times once a week with tirapazamine in two doses, 5 (5TP) and 10 mg/kg (10TP), while doxorubicin was administered in dose 1.8 mg/kg (DOX).
Subsequent two groups received both drugs simultaneously (5TP+DOX and 10TP+DOX).
Tirapazamine reduced heart lipid peroxidation and normalised RyR2 protein level altered by doxorubicin.
There were no significant changes in GSH/GSSG ratio, total glutathione, cTnI, AST, and SERCA2 level between DOX and TP+DOX groups.
Cardiomyocyte necrosis was observed in groups 10TP and 10TP+DOX.
American Psychological Association (APA)
Sliwinska, Justyna& Dudka, Jaroslaw& Korga, Agnieszka& Burdan, Franciszek& Matysiak, Wlodzimierz& Jodlowska-Jedrych, Barbara…[et al.]. 2012. Tirapazamine-Doxorubicin Interaction Referring to Heart Oxidative Stress and Ca2+ Balance Protein Levels. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-505770
Modern Language Association (MLA)
Sliwinska, Justyna…[et al.]. Tirapazamine-Doxorubicin Interaction Referring to Heart Oxidative Stress and Ca2+ Balance Protein Levels. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-505770
American Medical Association (AMA)
Sliwinska, Justyna& Dudka, Jaroslaw& Korga, Agnieszka& Burdan, Franciszek& Matysiak, Wlodzimierz& Jodlowska-Jedrych, Barbara…[et al.]. Tirapazamine-Doxorubicin Interaction Referring to Heart Oxidative Stress and Ca2+ Balance Protein Levels. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-505770
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505770