![](/images/graphics-bg.png)
Chorioamnionitis and Lung Injury in Preterm Newborns
Author
Source
Critical Care Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
There is a strong evidence that histologic chorioamnionitis is associated with a reduction of incidence and severity of respiratory distress syndrome (RDS).
Short-term maturational effects on the lungs of extremely premature infants seem to be, however, accompanied by a greater susceptibility of the lung, eventually contributing to an increased risk of bronchopulmonary dysplasia (BPD).
Genetic susceptibility to BPD is an evolving area of research and several studies have directly related the risk of BPD to genomic variants.
There is a substantial heterogeneity across the studies in the magnitude of the association between chorioamnionitis and BPD, and whether or not the association is statistically significant.
Considerable variation is largely dependent on differences of inclusion and exclusion criteria, as well as on clinical and histopathological definitions.
The presence of significant publication bias may exaggerate the magnitude of the association.
Controlling for publication bias may conduct to adjusted results that are no longer significant.
Recent studies generally seem to confirm the effect of chorioamnionitis on RDS incidence, while no effect on BPD is seen.
Recent data suggest susceptibility for subsequent asthma to be increased on long-term followup.
Additional research on this field is needed.
American Psychological Association (APA)
Rocha, Gustavo. 2013. Chorioamnionitis and Lung Injury in Preterm Newborns. Critical Care Research and Practice،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-505787
Modern Language Association (MLA)
Rocha, Gustavo. Chorioamnionitis and Lung Injury in Preterm Newborns. Critical Care Research and Practice No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-505787
American Medical Association (AMA)
Rocha, Gustavo. Chorioamnionitis and Lung Injury in Preterm Newborns. Critical Care Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-505787
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505787