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In Vitro Susceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide
Joint Authors
Rao, Sangeeta
Landolt, Gabriele A.
Ashton, Laura V.
Callan, Robert L.
Source
Veterinary Medicine International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Infection of dogs with canine influenza virus (CIV) is considered widespread throughout the United States following the first isolation of CIV in 2004.
While vaccination against influenza A infection is a common and important practice for disease control, antiviral therapy can serve as a valuable adjunct in controlling the impact of the disease.
In this study, we examined the antiviral activity of nitazoxanide (NTZ) and tizoxanide (TIZ) against three CIV isolates in vitro.
NTZ and TIZ inhibited virus replication of all CIVs with 50% and 90% inhibitory concentrations ranging from 0.17 to 0.21 μM and from 0.60 to 0.76 μM, respectively.
These results suggest that NTZ and TIZ are effective against CIV and may be useful for treatment of canine influenza in dogs but further investigation of the in vivo efficacy against CIV as well as the drug's potential for toxicity in dogs is needed.
American Psychological Association (APA)
Ashton, Laura V.& Callan, Robert L.& Rao, Sangeeta& Landolt, Gabriele A.. 2010. In Vitro Susceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide. Veterinary Medicine International،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-505788
Modern Language Association (MLA)
Ashton, Laura V.…[et al.]. In Vitro Susceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide. Veterinary Medicine International No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-505788
American Medical Association (AMA)
Ashton, Laura V.& Callan, Robert L.& Rao, Sangeeta& Landolt, Gabriele A.. In Vitro Susceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide. Veterinary Medicine International. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-505788
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505788